Eudragit
Polyacrylic resin is the cationic or anionic copolymer generated from the polymerization of DMAEMA dimethylaminoethyl methacrylate, methacrylic acid and methacrylic acid ester in different proportions.
Medicinal resin EUDRAGIT®
Chemical description: Polyacrylic resin is the cationic or anionic copolymer generated from the polymerization of DMAEMA dimethylaminoethyl methacrylate, methacrylic acid and methacrylic acid ester in different proportions. (The product meets USP/NF, Eur., Ph., JP pharmacopoeia standards)
Brand:Eudragit®
(Non-PH type)
General name
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Chemical compostion
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Solubility
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Appearance
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Main application
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RL 100
DMF# 1242
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Ethyl acrylate, methyl methacrylate, methyl methacrylate thrimethylamine ethyl ester chloride copolymer (1:2:0.2) |
water insoluble high permeablility
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Particle
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Sustained release coating |
RL PO
DMF# 1242
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Powder
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RL 30D
DMF# 1242
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30% aqueous dispersion
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RS 100
DMF# 1242
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Ethyl acrylate, methyl methacrylate, methyl methacrylate thrimethylamine ethyl ester chloride copolymer (1:2:0.1) |
Water insoluble low permeability |
Particle
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Sustained release coating
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RS PO
DMF# 1242
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Powder
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RS 30D
DMF# 1242
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30% aqueous dispersion
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NE 30D
DMF# 1242
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Ethyl acrylate, methyl methacrylate(2:1)copolymer |
Medium permeability
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30% aqueous dispersion
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Sustained release coating
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RD 100
DMF# 1242
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Eudragit RL and carboxymethycellulose sodium (9:1) compound |
Water insoluble
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Powder
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Rapid disintegrating moisture-proof coating
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(PH type)
Brand
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Chemical compostion
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Solubility
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Appearance
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Main application
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E 100
DMF# 1242
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Butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer (1:2:1) |
pH<5 dissolve
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Particle
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Rapid disintegrating coating material
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E PO
DMF# 1242
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Powder
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L30D-55
DMF# 2584
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Methacrylic acid, ethyl acrylate (1:1) |
pH>5.5 dissolve |
30% aqueous dispersion
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Enteric coating
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L100-55
DMF# 2584
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Powder
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L100
DMF# 1242
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Ethyl acrylate, methyl methacrylate(2:1) copolymer |
pH>6.0 dissolve
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Powder
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Enteric coating
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S 100
DMF# 1242
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Eudragit RL and carboxymethylcellulose sodium(9:1) compound |
pH>7.0 dissolve
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Powder
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Enteric coating
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Characteristics application:
Eudragit® polyacrylic resin is mainly used as the film-coat material of oral tablet and capsula which is applicable in transdermal casing pyl, and can also act as new-type gel in rectal administration. Direct compression process. Different types of polymer films vary in solubility.
>>RL, RS ,NE 30D are used as water-insoluble film-coating material in sustained release preparation. RL coating is better in permeability compared with RS coating. When compounding these two kinds coating material, you will gain film-coating with different permeability which can be made into wet particles with water and organic solvent to act as retarder. Large amount of dry polymer (5%~20%) can control the active principle's release from the matrix. Polymer with 10%~50% can adapt direct compression process.
>> L 30D-55 is the anionic moisture dispersion equivalent to C type methacrylic acid copolymer described by USP/NF20.
>> L 30D-55 acts as the enteric coating material of solid preparation which is insoluble in gastric juice but dissolves easily when pH value is above 5.5.
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