Hypromellose Metolose® HPMC
Chemical description: Hypromellose is the partially O-methylated and O-(2-hydroxypropylated) non-ionic water soluble cellulose ether derived from paper pulp . This product is insoluble in dehydrated alcohol, ether and acetone.
Brand: Metolose includes several types which have different substitution degree and categories.
General name
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Specification
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Labeled viscosity
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Methoxy,%
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Hydroxypropoxy,%
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Hypromellose
|
|
50
|
28.0-30.0
|
7.0-12.0
|
Hypromellose
|
60SH 4,000
DMF# 3748
|
4,000
|
28.0-30.0
|
7.0-12.0
|
Hypromellose
|
|
10,000
|
28.0-30.0
|
7.0-12.0
|
Hypromellose
|
90SH 4,000
DMF# 3748
|
4,000
|
19.0-24.0
|
7.0-12.0
|
Hypromellose
|
90SH 15,000
DMF# 3748
|
15,000
|
19.0-24.0
|
7.0-12.0
|
Hypromellose
|
90SH 100,000
DMF# 3748
|
100,000
|
19.0-24.0
|
7.0-12.0
|
Characteristics application:
Recommended application of HPMC (Metolose) produced by Shin-Etsu: low viscosity HPMC is used as binder, film coating, sustained release polymer materials, stabilizer, suspending agent and thickener in oral solid preparation.
60SH-50: Binder
60SH-50,60SH-4000; 90SH-4000, 90SH-4000 SR, 90-100,000 SR are used as hydrophilic matrix material for sustained release tablet.
60SH-4000,90SH-4000 are used as colloid drug. Ordinary brand's Metolose mean diameter is 70um, SR's mean diameter is 50um. HPMC's particle size distribution has certain effects on sustained release tablet's releasing.
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